Autoimmune hepatitis: Unveiling faces

被引:6
作者
Zhu, Jiang Yi [1 ]
Han, Ying [1 ]
机构
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Gastroenterol, Xian 710032, Shaanxi, Peoples R China
关键词
autoantibody; diagnosis; hepatitis; autoimmune; treatment; T-CELLS; LIVER-DISEASE; JAPANESE PATIENTS; TYPE-1; EPIDEMIOLOGY; PATHOGENESIS; DIAGNOSIS; POPULATION; MANAGEMENT; REMISSION;
D O I
10.1111/1751-2980.12285
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Autoimmune hepatitis (AIH) is a complex multifactorial liver disease with unknown etiology. It may be induced by certain triggers that cause immune disorders and autoimmune attack in genetically susceptible individuals, which ultimately results in chronic persistent interface inflammation of the liver. The diagnosis of AIH is made based on comprehensive evaluation score system. All AIH patients should receive interventions and the mainstay therapy is prednisone alone or in combination with azathioprine. Further exploratory researches on refractory AIH have been developed. Liver transplantation is still the only effective option for patients with decompensated cirrhosis or hepatic failure.
引用
收藏
页码:483 / 488
页数:6
相关论文
共 37 条
[1]   Autoimmune hepatitis (AIH) in the elderly: A systematic retrospective analysis of a large group of consecutive patients with definite AM followed at a tertiary referral centre [J].
Al-Chalabi, Thawab ;
Boccato, Sylvia ;
Portmann, Bernard C. ;
McFarlane, Ian G. ;
Heneghan, Michael A. .
JOURNAL OF HEPATOLOGY, 2006, 45 (04) :575-583
[2]   International Autoimmune Hepatitis Group Report:: review of criteria for diagnosis of autoimmune hepatitis [J].
Alvarez, E ;
Berg, PA ;
Bianchi, FB ;
Bianchi, L ;
Burroughs, AK ;
Cancado, EL ;
Chapman, RW ;
Cooksley, WGE ;
Czaja, AJ ;
Desmet, VJ ;
Donaldson, RT ;
Eddleston, ALWF ;
Fainboim, L ;
Heathcote, J ;
Homberg, JC ;
Hoofnagle, JH ;
Kakumu, S ;
Krawitt, EL ;
Mackay, IR ;
MacSween, RNM ;
Maddrey, WC ;
Manns, MP ;
McFarlane, IG ;
zum Büschenfelde, KHM ;
Mieli-Vergani, G ;
Nakanuma, Y ;
Nishioka, M ;
Penner, E ;
Porta, G ;
Portmann, BC ;
Reed, WD ;
Rodes, J ;
Schalm, SW ;
Scheuer, PJ ;
Schrumpf, E ;
Seki, T ;
Toda, G ;
Tsuji, T ;
Tygstrup, N ;
Vergani, D ;
Zeniya, M .
JOURNAL OF HEPATOLOGY, 1999, 31 (05) :929-938
[3]   Rituximab for the treatment of patients with autoimmune hepatitis who are refractory or intolerant to standard therapy [J].
Burak, Kelly W. ;
Swain, Mark G. ;
Santodomino-Garzon, Tania ;
Lee, Samuel S. ;
Urbanski, Stefan J. ;
Aspinall, Alexander I. ;
Coffin, Carla S. ;
Myers, Robert P. .
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 27 (05) :273-280
[4]   Antismooth Muscle and Antiactin Antibodies Are Indirect Markers of Histological and Biochemical Activity of Autoimmune Hepatitis [J].
Couto, Claudia A. ;
Bittencourt, Paulo L. ;
Porta, Gilda ;
Abrantes-Lemos, Clarice P. ;
Carrilho, Flair J. ;
Guardia, Bianca D. ;
Cancado, Eduardo L. R. .
HEPATOLOGY, 2014, 59 (02) :592-600
[5]   Clinical distinctions and pathogenic implications of type 1 autoimmune hepatitis in Brazil and the United States [J].
Czaja, AJ ;
Souto, EO ;
Bittencourt, PL ;
Cancado, ELR ;
Porta, G ;
Goldberg, AC ;
Donaldson, PT .
JOURNAL OF HEPATOLOGY, 2002, 37 (03) :302-308
[6]   Diagnosis and Management of Autoimmune Hepatitis [J].
Czaja, Albert J. .
CLINICS IN LIVER DISEASE, 2015, 19 (01) :57-79
[7]   Genetics of liver disease: Immunogenetics and disease pathogenesis [J].
Donaldson, PT .
GUT, 2004, 53 (04) :599-608
[8]  
Doniach D, 1966, Clin Exp Immunol, V1, P237
[9]   Recurrence of non-viral liver disease after orthotopic liver transplantation [J].
El-Masry, Monica ;
Gilbert, Carlos Puig ;
Saab, Sammy .
LIVER INTERNATIONAL, 2011, 31 (03) :291-302
[10]   A Multifaceted Imbalance of T Cells with Regulatory Function Characterizes Type 1 Autoimmune Hepatitis [J].
Ferri, Silvia ;
Longhi, Maria Serena ;
De Molo, Chiara ;
Lalanne, Claudine ;
Muratori, Paolo ;
Granito, Alessandro ;
Hussain, Munther J. ;
Ma, Yun ;
Lenzi, Marco ;
Mieli-Vergani, Giorgina ;
Bianchi, Francesco B. ;
Vergani, Diego ;
Muratori, Luigi .
HEPATOLOGY, 2010, 52 (03) :999-1007