Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

被引：46

作者：

Hu, Jun ^{[1
,2
]}

Yang, Qingjing ^{[1
,2
]}

Xu, Jianbin ^{[1
,2
]}

Huang, Chao ^{[1
,2
]}

Fan, Baomin ^{[1
,2
]}

Wang, Jun ^{[3
]}

Lin, Chengyuan ^{[3
]}

Bian, Zhaoxiang ^{[3
,4
]}

Chan, Albert S. C. ^{[4
]}

机构：

[1] Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Chem Ethn Med Resources, Kunming 650500, Peoples R China

[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650500, Peoples R China

[3] Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

[4] Hong Kong Baptist Univ, Inst Creat, Hong Kong, Hong Kong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 05期

基金：

中国国家自然科学基金;

关键词：

RING-OPENING REACTIONS; BICYCLIC ALKENES; OXABICYCLIC ALKENES; 2+2 CYCLOADDITION; NICKEL-COMPLEXES; AZABICYCLIC ALKENES; TERMINAL ALKYNES; EFFICIENT ROUTE; PALLADIUM; DERIVATIVES;

D O I：

10.1039/c2ob26775f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl](2) and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93% yield) and enantioselectivities (up to 85% ee).

引用

页码：814 / 820

页数：7

共 59 条

[21] [2+2] DIMERIZATION OF NORBORNADIENE AND ITS DERIVATIVES IN THE PRESENCE OF NICKEL-COMPLEXES AND ZINC METAL [J].