Prodrugs for transdermal drug delivery - trends and challenges

被引：23

作者：

Ita, Kevin B. ^{[1
]}

机构：

[1] Touro Univ Calif, Dept Biol & Pharmaceut Sci, Coll Pharm, Vallejo, CA USA

来源：

JOURNAL OF DRUG TARGETING | 2016年 / 24卷 / 08期

关键词：

Chemical synthesis; drug delivery; prodrugs; transdermal; SKIN IN-VITRO; PERCUTANEOUS-ABSORPTION; CARBAMATE PRODRUGS; ETHYLENEOXY GROUPS; DESIGN; PENETRATION; PERMEATION; NALTREXONE; STRATEGIES; ZIDOVUDINE;

D O I：

10.3109/1061186X.2016.1154562

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prodrugs continue to attract significant interest in the transdermal drug delivery field. These moieties can confer favorable physicochemical properties on transdermal drug delivery candidates. Alkyl chain lengthening, pegylation are some of the strategies used for prodrug synthesis. It is usually important to optimize partition coefficient, water and oil solubilities of drugs. In this review, progress made in the field of prodrugs for percutaneous penetration is highlighted and the challenges discussed.

引用

页码：671 / 678

页数：8

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