Antifungal bis[bibenzyls] from the Chinese liverwort Marchantia polymorpha L.

被引:93
作者
Niu, C [1 ]
Qu, JB [1 ]
Lou, HX [1 ]
机构
[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China
关键词
D O I
10.1002/cbdv.200690004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bioassay-guided separation of the antifungal constituents of the Chinese liverwort Marchantia polymorpha L. (Marchantiaceae) led to the isolation of seven bis[bibenzyl]-type macrocycles. On the basis of NMR and MS analyses, the three new compounds plagiochin E (1), 13,13'-O-isoproylidenericcardin D (4), and riccardin H (7) were identified, together with four known compounds: marchantin E (2), neomarchantin A (3), marchantin A (5), and marchantin B (6). Their antifungal activities against Candida albicans were determined by TLC bioautography.
引用
收藏
页码:34 / 40
页数:7
相关论文
共 15 条
[1]  
ASAKAWA Y, 1983, J ORG CHEM, V48, P2164, DOI 10.1021/jo00161a009
[2]   Recent advances in phytochemistry of bryophytes-acetogenins, terpenoids and bis(bibenzyl)s from selected Japanese, Taiwanese, New Zealand, Argentinean and European liverworts [J].
Asakawa, Y .
PHYTOCHEMISTRY, 2001, 56 (03) :297-312
[3]   CHEMOSYSTEMATICS OF BRYOPHYTES .34. ENT-SESQUITERPENOIDS AND CYCLIC BIS(BIBENZYLS) FROM THE GERMAN LIVERWORT MARCHANTIA-POLYMORPHA [J].
ASAKAWA, Y ;
TORI, M ;
MASUYA, T ;
FRAHM, JP .
PHYTOCHEMISTRY, 1990, 29 (05) :1577-1584
[4]  
ASAKAWA Y, 1995, PROGR CHEM ORG NATUR, P473
[5]   PLAGIOCHIN-A, PLAGIOCHIN-B, PLAGIOCHIN-C, AND PLAGIOCHIN-D, NEW TYPE OF MACROCYCLIC BIS(BIBENZYLS) HAVING A BIPHENYL LINKAGE BETWEEN THE ORTHO-POSITIONS TO THE BENZYL METHYLENES, FROM THE LIVERWORT PLAGIOCHILA-ACANTHOPHYLLA SUBSP JAPONICA [J].
HASHIMOTO, T ;
TORI, M ;
ASAKAWA, Y ;
FUKAZAWA, Y .
TETRAHEDRON LETTERS, 1987, 28 (50) :6295-6298
[6]   DIRECT BIOAUTOGRAPHY ON THIN-LAYER CHROMATOGRAMS AS A METHOD FOR DETECTING FUNGITOXIC SUBSTANCES [J].
HOMANS, AL ;
FUCHS, A .
JOURNAL OF CHROMATOGRAPHY, 1970, 51 (02) :327-&
[7]  
JOCHENS MS, 2002, TETRAHEDRON, V58, P7875
[8]   BIOSYNTHESIS AND MOLECULAR STRAIN - A COMPUTATIONAL STUDY ON THE CONFORMATION OF CYCLIC BIS(BIBENZYL) CONSTITUENTS OF LIVERWORT SPECIES [J].
KESERU, GM ;
NOGRADI, M .
PHYTOCHEMISTRY, 1992, 31 (05) :1573-1576
[9]   A cytotoxic diterpenoid and antifungal phenolic compounds from Frullania muscicola steph [J].
Lou, HX ;
Li, GY ;
Wang, FQ .
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2002, 4 (02) :87-94
[10]  
MOTOO T, 1985, TETRAHEDRON LETT, V26, P4735