Association of Serum Cytokines, Human Growth Hormone, Insulin-Like Growth Factor (IGF)-I, IGF-II and IGF-Binding Protein (IGFBP)-3 with Coronary Artery Disease

被引：8

作者：

Hu, Wei-Syun ^{[1
,2
]}

Hwang, Jin-Ming ^{[3
]}

Tsai, Ying-Lan ^{[4
]}

Kuo, Chia-Hua ^{[5
]}

Jong, Gwo-Ping ^{[6
]}

Kuo, Wu-Hsien ^{[7
]}

Tsai, Fuu-Jen ^{[8
]}

Tsai, Chang-Hai ^{[9
]}

Chung, Li-Chin ^{[10
]}

Huang, Chih-Yang ^{[8
,11
]}

机构：

[1] Taipei Med Univ, Shuang Ho Hosp, Div Cardiol, Taipei 23561, Taiwan

[2] China Med Univ, Grad Inst Aging Med, Taichung 40402, Taiwan

[3] Chung Shan Med Univ, Sch Appl Chem, Taichung 40201, Taiwan

[4] Natl Taiwan Sport Univ, Athlet Training & Hlth Dept, Tao Yuan 33301, Taiwan

[5] Taipei Sports Univ, Lab Exercise Biochem, Taipei 11153, Taiwan

[6] Armed Force Taichung Gen Hosp, Dept Internal Med, Div Cardiol, Taichung 40042, Taiwan

[7] Taichung Gen Hosp, Dept Internal Med, Div Gastroenterol, Taichung 40042, Taiwan

[8] China Med Univ, Grad Inst Chinese Med Sci, Taichung 40402, Taiwan

[9] Asia Univ, Dept Healthcare Adm, Taichung 41354, Taiwan

[10] Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm, Tainan 71710, Taiwan

[11] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 41354, Taiwan

来源：

CHINESE JOURNAL OF PHYSIOLOGY | 2012年 / 55卷 / 04期

关键词：

cytokines; insulin-like growth factor-I; insulin-like growth factor-II; insulin-like growth factor binding protein-3; myocardial infarction; percutaneous coronary intervention; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION; UNSTABLE ANGINA; CARDIOVASCULAR-DISEASE; GUIDELINE UPDATE; FOCUSED UPDATE; STABLE ANGINA; RISK-FACTORS; INTERLEUKIN-10;

D O I：

10.4077/CJP.2012.BAA043

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The roles that serum cytokines, human growth hormone (h-GH), insulin-like growth factor (IGF)-I, IGF-II and IGF-binding protein (IGFBP)-3 play in coronary artery disease (CAD) are not completely clear. A total of 80 participants comprising 20 patients with stable angina (SA), 20 patients with unstable angina (UA), 20 patients with myocardial infarction (MI) and 20 healthy control subjects were recruited during the period January 2010 to August 2010. Blood samples were drawn from all participants on admission and one week later in MI patients undergoing percutaneous coronary intervention (PCI). We found that MI patients had significantly lower levels of IGF-I, IGF-II and IGFBP-3, and significantly higher levels of h-GH, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 than controls. Furthermore, patients with SA or UA had higher levels of TNF-alpha and lower levels of IGF-II than control subjects. Moreover, h-GH, IGF-I, IGF-II, IGFBP-3 and IL-6 levels returned to within normal range in MI patients one week after PCI. Our preliminary findings suggest that TNF-alpha and IGF-II are potential biomarkers of early CAD. Furthermore, h-GH, IGF-I, IGF-II, IGFBP-3 and IL-6 might be predictors of and potential modifiable targets for MI.

引用

页码：267 / 273

页数：7