The Effect of Camphor and Borneol on Rat Thymocyte Viability and Oxidative Stress

被引：29
|
作者：
Cherneva, Emiliya [1 ]
Pavlovic, Voja [2 ]
Smelcerovic, Andrija [3 ]
Yancheva, Denitsa [4 ]
机构：
[1] Med Univ Sofia, Fac Pharm, Dept Chem, Sofia 1000, Bulgaria
[2] Univ Nis, Fac Med, Inst Physiol, Nish 18000, Serbia
[3] Univ Nis, Fac Med, Dept Pharm, Nish 18000, Serbia
[4] Bulgarian Acad Sci, Inst Organ Chem, Ctr Phytochem, BU-1113 Sofia, Bulgaria
来源：
MOLECULES | 2012年 / 17卷 / 09期
关键词：
camphor; borneol; cytotoxicity; oxidative stress; mitochondrial membrane potential; ESSENTIAL OILS; APOPTOSIS; CELLS; CYTOTOXICITY; MICE;
D O I：
10.3390/molecules170910258
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Camphor and borneol are wildly distributed in the essential oils of medicinal plants from various parts of the World. Our study has been carried out to evaluate the effect of these two bicyclic monoterpenes on rat thymocytes. Camphor and borneol at concentrations of 0.5 and 5 mu g/mL did not induce significant toxicity on the immune system cells, while a significant increase of thymocyte viability was detected when cells were incubated with 50 mu g/mL of camphor. A significant increase of cell viability was similarly detected when thymocytes were cultivated with borneol at concentrations of 0.5 and 5 mu g/mL. The role of camphor and borneol in reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) disturbances in rat thymocytes as well as their potential mechanism(s) of action were also discussed.
引用
收藏
页码：10258 / 10266
页数：9
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