Neuroimaging Studies in Insomnia

被引:43
作者
Spiegelhalder, Kai [1 ,2 ]
Regen, Wolfram [1 ]
Baglioni, Chiara [1 ]
Riemann, Dieter [1 ]
Winkelman, John W. [3 ]
机构
[1] Univ Freiburg, Med Ctr, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany
[2] Univ Freiburg, Freiburg Inst Adv Studies FRIAS, D-79104 Freiburg, Germany
[3] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
关键词
Insomnia; Sleep disorders; Neuroimaging; Neurobiology; Psychiatry; MAGNETIC-RESONANCE-SPECTROSCOPY; HEART-RATE-VARIABILITY; CORTICAL GABA LEVELS; NREM SLEEP; HIPPOCAMPAL VOLUME; ATTENTIONAL BIAS; NEURAL CIRCUITRY; EEG ACTIVITY; PERFORMANCE; DISABILITY;
D O I
10.1007/s11920-013-0405-0
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Chronic insomnia is one of the most prevalent psychiatric disorders and has a significant impact on individual's health. However, the pathophysiology of the disorder is poorly understood. The current review focuses on neuroimaging findings in insomnia. In summary, the current data suggest the following: (1) insomnia is characterized by corticolimbic overactivity during sleep and wakefulness that interferes with sleep initiation and/or maintenance; (2) insomnia patients' daytime performance is associated with a hypoactivation of task-related areas; (3) neurochemically, insomnia patients are probably characterized by reduced cortical GABA levels; (4) insomnia may be associated with abnormal brain morphometry in the frontal cortex, hippocampus and/or anterior cingulate cortex. Future investigations should include larger sample sizes or longitudinal within-subject comparisons. Other possible methodological improvements are discussed.
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页数:6
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