Synthesis and photophysical characterization of highly water-soluble PEGylated BODIPY derivatives for cellular imaging

被引：16

作者：

Badon, Isabel Wen ^{[1
]}

Lee, Joomin ^{[2
]}

Vales, Temmy Pegarro ^{[1
,3
]}

Cho, Byoung Ki ^{[4
]}

Kim, Ho-Joong ^{[1
]}

机构：

[1] Chosun Univ, Dept Chem, Gwangju 61452, South Korea

[2] Chosun Univ, Dept Food & Nutr, Gwangju 61452, South Korea

[3] Caraga State Univ, Dept Nat Sci, Butuan City 8600, Philippines

[4] Dankook Univ, Dept Chem, Chungnam 31116, South Korea

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2019年 / 377卷

关键词：

BODIPY; Fluorescent probes; Poly(ethylene glycol); Water-soluble; Bioimaging agents; FLUORESCENCE; DYES; BIOMOLECULES; EMISSION; PROBES;

D O I：

10.1016/j.jphotochem.2019.03.050

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of poly(ethylene glycol) (PEG)-modified water-soluble boron dipyrromethene (BODIPY) dyes (EtBOD-PEG and BOD-PEG) were synthesized and their photophysical properties in various solutions were investigated. The presence of ethyl groups at the 2,6-positions of the BODIPY core in EtBOD-PEG resulted in bathochromic shifts in both the absorption and emission spectra relative to those of the unsubstituted BOD-PEG. Importantly, bulky di-branched PEG chains were introduced at the meso position of the BODIPY core, leading to enhanced solubilities and high fluorescence quantum yields in aqueous solutions. The water-soluble BODIPY dyes were explored for their applicability in fluorescent bio-imaging using MCF-7 human breast cancer cells. The dyes were cell-permeable and were concentrated in cellular cytoplasm area, suggesting that they have potential applications as bio-imaging agents.

引用

页码：214 / 219

页数：6

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