Revealing the anti-tumoral effect of Algerian Glaucium flavum roots against human cancer cells

被引：17

作者：

Bournine, Lamine ^{[1
,2
,3
]}

Bensalem, Sihem ^{[1
]}

Peixoto, Paul ^{[2
]}

Gonzalez, Arnaud ^{[2
]}

Maiza-Benabdesselam, Fadila ^{[1
]}

Bedjou, Fatiha ^{[1
]}

Wauters, Jean-Noel ^{[3
]}

Tits, Monique ^{[3
]}

Frederich, Michel ^{[3
]}

Castronovo, Vincent ^{[2
]}

Bellahcene, Akeila ^{[2
]}

机构：

[1] Univ Bejaia, Fac Nat Sci & Life, Lab Plant Biotechnol & Ethnobot, Bejaia, Algeria

[2] Univ Liege, GIGA Canc, Metastasis Res Lab, B-4000 Liege, Belgium

[3] Univ Liege, CIRM, Lab Pharmacognosy, B-4000 Liege, Belgium

来源：

PHYTOMEDICINE | 2013年 / 20卷 / 13期

关键词：

Glaucium flavum; Breast cancer; Growth inhibition; Cell cycle arrest; Apoptosis; THERAPEUTIC TARGETS; IN-VITRO; APOPTOSIS; CYCLE; SANGUINARINE; ALKALOIDS; CULTURE; MITOSIS; DEATH; VIVO;

D O I：

10.1016/j.phymed.2013.06.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Glaucium flavum (G. flavum) is a plant from the Papaveraceae family native to Algeria where it is used in local traditional medicine to treat warts. G. flavum root crude alkaloid extract inhibited breast cancer cell proliferation and induced G2/M phase cycle arrest and apoptosis without affecting normal cells, which is a highly awaited feature of potential anti-cancer agents. G. flavum significantly reduced growth and vascularization of human glioma tumors on chicken chorioallantoic membrane (CAM) in vivo. The chromatographic profile of the dichloromethane extract of G.flavum root showed the presence of different constituents including the isoquinoline alkaloid protopine, as the major compound. We report for the first time that G. flavum extract may represent a new promising agent for cancer chemotherapy. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：1211 / 1218

页数：8

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