Accuracy and precision of transcutaneous bilirubinometry in postdischarge Asian neonates

A prospective cross-sectional study was conducted in a tertiary care center to determine the accuracy of transcutaneous bilirubin measurements (TcB) measured by the Konica Minolta JM-103 (TM) meter compared to total serum bilirubin (TSB) in Asian infants aged 5-14 days. There were 405 late-preterm and term infants involved, and 455 paired samples were obtained by venepuncture and analyzed for bilirubin levels. TcB measurements were performed using the average of three measurements (TcB3) and a single measurement (TcB1) method. The overall correlation between TSB and the TcB was 0.80 (p a parts per thousand currency signaEuro parts per thousand 0.001) for TcB3 and 0.76 (p a parts per thousand currency signaEuro parts per thousand 0.001) for TcB1, respectively. The mean (SD) difference between TcB3 and TSB was -17.6 (29.5) mu mol/L (median, -17.0; interquartile range (IQR), -39.1 to 1.7) and between TcB1 and TSB was -20.7 (32.3) mu mol/L (median, -20.4; IQR, -42.5 to 1.7). The mean difference (SD) between the TcB3 and TSB in the low-risk (TSB < 170 mu mol/L), intermediate-risk (TSB 170-254 mu mol/L), and high-risk (TSB a parts per thousand yenaEuro parts per thousand 255 mu mol/L) groups was -2.8 (27.2), -13.4 (27.0), and -33.4 (29.1) mu mol/L, respectively. To detect a TSB level of a parts per thousand yen255 mu mol/L, using the TcB cutoff level of 204 mu mol/L provides a sensitivity of 96 % with a specificity of 58 %. Conclusion: The TcB meter using a specific cutoff level can be reliably used as a screening tool for jaundice detection in older, postdischarge neonates, including the Asian population. Lower cutoff values can be set to capture all infants who merit closer surveillance, potential investigation, and treatment with higher accompanying screening costs.