Screening and determination of drugs in human saliva utilizing microextraction by packed sorbent and liquid chromatography-tandem mass spectrometry

被引：38

作者：

Abdel-Rehim, Abbi ^{[1
]}

Abdel-Rehim, Mohamed ^{[1
]}

机构：

[1] Stockholm Univ, Dept Analyt Chem, SE-10691 Stockholm, Sweden

来源：

BIOMEDICAL CHROMATOGRAPHY | 2013年 / 27卷 / 09期

关键词：

eVol; MEPS; LC-MS/MS; lidocaine; saliva samples; HUMAN URINE SAMPLES; HUMAN PLASMA; SYRINGE MEPS; LOCAL-ANESTHETICS; ONLINE MICROEXTRACTION; MICRO-EXTRACTION; LC; QUANTIFICATION; METABOLITES; POLYMER;

D O I：

10.1002/bmc.2925

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This study presents a new method for collecting and handling saliva samples using an automated analytical microsyringe and microextraction by packed syringe (MEPS). The screening and determination of lidocaine in human saliva samples utilizing MEPS and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were carried out. An exact volume of saliva could be collected. The MEPS C-8-cartridge could be used for 50 extractions before it was discarded. The extraction recovery was about 60%. The pharmacokinetic curve of lidocaine in saliva using MEPS-LC-MS/MS is reported. Copyright (C) 2013 John Wiley & Sons, Ltd.

引用

页码：1188 / 1191

页数：4

共 36 条

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[5]

2-F

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Abdel-Rehim, Mohamed ;

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JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2008, 46 (06) :518-523

[7] Simultaneous determination of busulphan in plasma samples by liquid chromatography-electrospray ionization mass spectrometry utilizing microextraction in packed syringe (MEPS) as on-line sample preparation method [J].

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Hassan, Moustapha .

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2007, 30 (20) :3029-3041

[8] Microextraction in packed syringe (MEPS) utilizing methylcyanopropyl-silarylene as coating polymer for extraction of drugs in biological samples [J].

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Tabacchi, Raphael .

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2006, 29 (17) :2537-2544

[9] Quantification of 4-OH-2,6-xylidine and its conjugates in human urine samples utilising microextraction in packed syringe on-line with liquid chromatography and electrospray tandem mass spectrometry (MEPS-LC-MS/MS) [J].

Abdel-Rehim, Mohamed ;

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JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2006, 29 (16) :2413-2424

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Abdel-Rehim, Mohamed ;

Dahlgren, Marie ;

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JOURNAL OF SEPARATION SCIENCE, 2006, 29 (11) :1658-1661

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