Nanoscopic insights into the surface conformation of neurotoxic amyloid β oligomers

被引:20
作者
Banchelli, Martina [1 ]
Cascella, Roberta [2 ]
D'Andrea, Cristiano [1 ]
Cabaj, Leszek [3 ]
Osticioli, Iacopo [1 ]
Ciofini, Daniele [1 ]
Li, Mai Suan [4 ,5 ]
Skupien, Krzysztof [3 ]
de Angelis, Marella [1 ]
Siano, Salvatore [1 ]
Cecchi, Cristina [2 ]
Pini, Roberto [1 ]
La Penna, Giovanni [6 ]
Chiti, Fabrizio [2 ]
Matteini, Paolo [1 ]
机构
[1] CNR, Inst Appl Phys Nello Carrara, Via Madonna Piano 10, I-50019 Sesta Fiorentino, Italy
[2] Univ Florence, Dept Expt & Clin Biomed Sci, Viale Morgagni 50, I-50134 Florence, Italy
[3] 3D Nano, PL-30702 Krakow, Poland
[4] Polish Acad Sci, Inst Phys, Al Lotnikow 32-46, PL-02668 Warsaw, Poland
[5] Inst Computat Sci & Technol, SBI Bldg,Dist 12, Ho Chi Minh City, Vietnam
[6] CNR, Inst Chem Organometall Cpds, Via Madonna Piano 10, I-50019 Sesto Fiorentino, Italy
关键词
ENHANCED RAMAN-SPECTROSCOPY; SILVER NANOPARTICLES; FIBRIL FORMATION; PROTEIN; PHENYLALANINE; SCATTERING; FEATURES; TYROSINE; PROGRESS; DISEASE;
D O I
10.1039/d0ra03799k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Raman spectroscopy assisted by localized plasmon resonances generating effective hot spots at the gaps between intertwined silver nanowires is herein adopted to unravel characteristic molecular motifs on the surface of A beta(42)misfolded oligomers that are critical in driving intermolecular interactions in neurodegeneration.
引用
收藏
页码:21907 / 21913
页数:7
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