Cell membrane mimetic copolymer coated polydopamine nanoparticles for combined pH-sensitive drug release and near-infrared photothermal therapeutic

被引:27
|
作者
Wang, Linlin [1 ]
Dai, Wei [1 ]
Yang, Meng [1 ]
Wei, Xinran [1 ]
Ma, Ke [1 ]
Song, Botao [1 ]
Jia, Pengxiang [1 ]
Gong, Yongkuan [1 ]
Yang, Jingfa [2 ]
Zhao, Jiang [2 ]
机构
[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710127, Shaanxi, Peoples R China
[2] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
基金
中国国家自然科学基金;
关键词
PMPC-b-PDMAEMA; Polydopamine nanoparticles; pH-sensitive; Photothermal; DOPAMINE; NANOHYDROGELS; NANOCARRIERS; VERSATILE; MICELLES; DELIVERY; ALBUMIN;
D O I
10.1016/j.colsurfb.2018.12.057
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
In this study, we modified the well-known photothermal polydopamine nanoparticles with the poly[(2-methacryloyloxy)ethyl phosphorylcholine-b-(2-dimethylamino)ethyl methacrylate) (PMPC-b-PDMAEMA) diblock copolymers, containing both biocompatible cell membrane phosphorylcholine zwitterions segments and pH-responsive dimethylaminoethyl units on the polymer chains, to achieve both the photothermal property and pH responsive release behavior. The results showed that the obtained nanoparticles had a narrow size distribution with the diameter about 220 nm. Besides, the modified polydopamine nanoparticles showed enhanced colloidal stability, pH-sensitive drug release behavior, excellent biocompatibility and remarkable near-infrared photo thermal property. Thus, it is highly anticipated that PMPC-b-PDMAEMA modified polydopamine nanoparticles can serve as a powerful drug delivery system for combined pH-sensitive drug release and near-infrared photo thermal therapeutic.
引用
收藏
页码:1 / 8
页数:8
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