In Vitro Activities of Antifungal Agents against Clinical Isolates of Dermatophytes from Animals

被引：30

作者：

Itoi, Sayuri ^{[1
]}

Kano, Rui ^{[1
]}

Hasegawa, Atsuhiko ^{[2
]}

Kamata, Hiroshi ^{[1
]}

机构：

[1] Nihon Univ, Sch Vet Med, Dept Pathobiol, Fujisawa, Kanagawa 2520880, Japan

[2] Teikyo Univ, Inst Med Mycol, Hachioji, Tokyo 1920395, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2012年 / 74卷 / 08期

关键词：

azole; dermatophyte; drug susceptibility; terbinafine; SUSCEPTIBILITY; STRAINS;

D O I：

10.1292/jvms.12-0057

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Although the susceptibility of dermatophytes to anti fungal drugs is well documented in humans, the effectiveness in animals has not been previously investigated. The in vitro susceptibility of 54 clinical isolates from animal dermatophytoses to ketoconazole (KTZ), itaconazole (ITZ) and terbinafine (TFN) was measured using microdilution assay (CLSI M38-A2 test) and by the E-test (KTZ and ITZ). All 3 drugs showed anti fungal activity, while KTZ displayed the broadest minimum inhibition concentration (MIC) rang (0.125-16 mu g/ml) against M. canis and M. gypseuni. The MIC of KTZ and TFN was almost the same for human and animal isolates of T mentagrophytes and T. rubrum. The MIC of TFN was almost the same for dermatophytes isolated from humans and animals.

引用

页码：1067 / 1069

页数：3

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