Distinct reactivity of Pd(OTs)2:: The intermolecular Pd(II)-catalyzed 1,2-carboamination of dienes

被引：305

作者：

Houlden, Chris E. ^{[1
]}

Bailey, Chris D. ^{[1
]}

Ford, J. Gair ^{[2
]}

Gagne, Michel R. ^{[3
]}

Lloyd-Jones, Guy C. ^{[1
]}

Booker-Milburn, Kevin I. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] AstraZeneca PR&D, Macclesfield SK10 2NA, Cheshire, England

[3] Univ N Carolina, Dept Chem, Caudill & Kenan Labs, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 31期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ja803397y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Pd-catalysed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ generation or preformation, os palladium tosylate emerges as a key parameter in gaining the requisite reacticity for the C-H insertion/carbopalladation/nucleophilic displacement process.

引用

页码：10066 / +

页数：3

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