An updated perspective on the polymerase division of labor during eukaryotic DNA replication

被引：43

作者：

Guilliam, Thomas A. ^{[1
]}

Yeeles, Joseph T. P. ^{[1
]}

机构：

[1] MRC, Lab Mol Biol, Div Prot & Nucle Acid Chem, Cambridge CB2 0QH, England

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2020年 / 55卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

DNA replication; replisome; DNA polymerase; polymerase delta; replication fork; BREAK-INDUCED REPLICATION; LEADING-STRAND SYNTHESIS; RIBONUCLEOTIDE INCORPORATION; DEOXYRIBONUCLEIC-ACID; CATALYTIC DOMAINS; POL EPSILON; IN-VIVO; MECHANISMS; DELTA; YEAST;

D O I：

10.1080/10409238.2020.1811630

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotes three DNA polymerases (Pols), alpha, delta, and epsilon, are tasked with bulk DNA synthesis of nascent strands during genome duplication. Most evidence supports a model where Pol alpha initiates DNA synthesis before Pol epsilon and Pol delta replicate the leading and lagging strands, respectively. However, a number of recent reports, enabled by advances in biochemical and genetic techniques, have highlighted emerging roles for Pol delta in all stages of leading-strand synthesis; initiation, elongation, and termination, as well as fork restart. By focusing on these studies, this review provides an updated perspective on the division of labor between the replicative polymerases during DNA replication.

引用

页码：469 / 481

页数：13

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