Distribution of amantadine-resistant H5N1 avian influenza variants in Asia

被引：216

作者：

Cheung, Chung-Lam

Rayner, Jane M.

Smith, Gavin J. D.

Wang, Pui

Naipospos, T. S. P.

Zhang, Jinxia

Yuen, Kwok-Yung

Webster, Robert G.

Peiris, J. S. Malik

Guan, Yi

Chen, Honglin

机构：

[1] Univ Hong Kong, Fac Med, Dept Microbiol, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China

[2] Shantou Univ, Coll Med, Joint Influenza Res Ctr, Shantou, Guangdong, Peoples R China

[3] St Jude Childrens Res Hosp, Div Virol, Dept Infect Dis, Memphis, TN 38105 USA

[4] Ctr Indonesian Vet Analyt Studies, Jakarta, Indonesia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 193卷 / 12期

关键词：

D O I：

10.1086/504723

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane derivatives, amantadine and rimantadine, among H5N1 viruses isolated in Vietnam, Thailand, Cambodia, Indonesia, Hong Kong, and China. More than 95% of the viruses isolated in Vietnam and Thailand contained resistance mutations, but resistant mutants were less commonly isolated in Indonesia (6.3% of isolates) and China (8.9% of isolates), where human infection was recently reported. The dual mutation motif Leu26Ile-Ser31Asn (leucine -> isoleucine at aa 26 and serine -> asparagine at aa 31) was found almost exclusively in all resistant isolates from Vietnam, Thailand, and Cambodia, suggesting the biological selection of these mutations.

引用

页码：1626 / 1629

页数：4

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