Solvent- and catalyst-free synthesis of imidazo[1,2-a]pyridines under microwave irradiation

被引：9

作者：

Kong, Dulin ^{[1
,2
]}

Wang, Xianghui ^{[3
]}

Shi, Zaifeng ^{[3
]}

Wu, Mingshu ^{[3
]}

Lin, Qiang ^{[2
,3
]}

Wang, Xin ^{[2
]}

机构：

[1] Hainan Med Univ, Sch Pharmaceut Sci, Haikou 571199, Hainan Province, Peoples R China

[2] Nanjing Univ Sci & Technol, Minist Educ, Key Lab Soft Chem & Funct Mat, Nanjing 210094, Jiangsu, Peoples R China

[3] Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571158, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2016年 / 09期

关键词：

imidazo[1,2-a]pyridines; microwave irradiation; catalyst-free; INHIBITORS; POTENT;

D O I：

10.3184/174751916X14683327937934

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile solvent- and catalyst-free method for the synthesis of a series of imidazo[1,2-a]pyridines in good to excellent yields by the condensation of 2-aminopyridines with a-bromoketones under microwave irradiation has been developed. The important features of this method are that it is reasonably fast, very clean, high yielding, simple workup and environmentally benign.

引用

页码：529 / 531

页数：3

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