Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans

被引：2

作者：

Choi, Jae Yong ^{[1
]}

Lyoo, Chul Hyoung ^{[2
]}

Kim, Jin Su ^{[3
]}

Kim, Kyeong Min ^{[3
]}

Lee, Minkyung ^{[4
]}

Ryu, Young Hoon ^{[1
]}

机构：

[1] Yonsei Univ, Gangnam Severance Hosp, Dept Nucl Med, Coll Med, Seoul, South Korea

[2] Yonsei Univ, Gangnam Severance Hosp, Dept Neurol, Coll Med, Seoul, South Korea

[3] Korea Inst Radiol & Med Sci, Mol Imaging Res Ctr, Seoul, South Korea

[4] Inha Univ Hosp, Dept Nucl Med, Inha Coll Med, Inchon, South Korea

来源：

MOLECULAR IMAGING AND BIOLOGY | 2016年 / 18卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

5-HT1A receptor; PET; Dosimetry; F-18]Mefway; RECEPTOR-BINDING; PET; RADIOLIGAND; BRAIN;

D O I：

10.1007/s11307-016-0955-8

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

[F-18]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [F-18]Mefway in humans. Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [F-18]Mefway (226 +/- 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. [F-18]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35-22.87 mu Sv/MBq, radiation dose in the urinary bladder wall was 471 mu Sv/MBq. The mean effective dose was 40.23 +/- 6.63 mu Sv/MBq. For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [F-18]Mefway PET scan.

引用

页码：803 / 806

页数：4

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[21] Radiation dosimetry and biodistribution in non-human primates of the sodium/iodide PET ligand [18F]-tetrafluoroborate [J].

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Hinnen, F ;

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