Hippocampal SWR Activity Predicts Correct Decisions during the Initial Learning of an Alternation Task

被引：165
作者：
Singer, Annabelle C. [1 ,2 ,3 ,4 ]
Carr, Margaret F. [3 ,4 ,5 ]
Karlsson, Mattias P. [3 ,4 ,6 ]
Frank, Loren M. [3 ,4 ]
机构：
[1] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA
[2] MIT, MIT Media Lab, Cambridge, MA 02139 USA
[3] Univ Calif San Francisco, Ctr Integrat Neurosci, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
[5] Stanford Univ, CNC Program, Stanford, CA 94305 USA
[6] HHMI, Ashburn, VA 20147 USA
来源：
NEURON | 2013年 / 77卷 / 06期
基金：
美国国家卫生研究院;
关键词：
SPATIAL MEMORY; AWAKE STATE; EXPERIENCE; REPLAY; REACTIVATION; RIPPLES; CONSOLIDATION; SEQUENCES;
D O I：
10.1016/j.neuron.2013.01.027
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The hippocampus frequently replays memories of past experiences during sharp-wave ripple (SWR) events. These events can represent spatial trajectories extending from the animal's current location to distant locations, suggesting a role in the evaluation of upcoming choices. While SWRs have been linked to learning and memory, the specific role of awake replay remains unclear. Here we show that there is greater coordinated neural activity during SWRs preceding correct, as compared to incorrect, trials in a spatial alternation task. As a result, the proportion of cell pairs coactive during SWRs was predictive of subsequent correct or incorrect responses on a trial-by-trial basis. This effect was seen specifically during early learning, when the hippocampus is essential for task performance. SWR activity preceding correct trials represented multiple trajectories that included both correct and incorrect options. These results suggest that reactivation during awake SWRs contributes to the evaluation of possible choices during memory-guided decision making.
引用
收藏
页码：1163 / 1173
页数：11
相关论文
共 26 条
[11]   Trajectory encoding in the hippocampus and entorhinal cortex [J].
Frank, LM ;
Brown, EN ;
Wilson, M .
NEURON, 2000, 27 (01) :169-178
[12]   Hippocampal plasticity across multiple days of exposure to novel environments [J].
Frank, LM ;
Stanley, GB ;
Brown, EN .
JOURNAL OF NEUROSCIENCE, 2004, 24 (35) :7681-7689
[13]   Selective suppression of hippocampal ripples impairs spatial memory [J].
Girardeau, Gabrielle ;
Benchenane, Karim ;
Wiener, Sidney I. ;
Buzsaki, Gyoergy ;
Zugaro, Michael B. .
NATURE NEUROSCIENCE, 2009, 12 (10) :1222-1223
[14]   Hippocampal Replay Is Not a Simple Function of Experience [J].
Gupta, Anoopum S. ;
van der Meer, Matthijs A. A. ;
Touretzky, David S. ;
Redish, A. David .
NEURON, 2010, 65 (05) :695-705
[15]   Awake Hippocampal Sharp-Wave Ripples Support Spatial Memory [J].
Jadhav, Shantanu P. ;
Kemere, Caleb ;
German, P. Walter ;
Frank, Loren M. .
SCIENCE, 2012, 336 (6087) :1454-1458
[16]   Neural ensembles in CA3 transiently encode paths forward of the animal at a decision point [J].
Johnson, Adam ;
Redish, A. David .
JOURNAL OF NEUROSCIENCE, 2007, 27 (45) :12176-12189
[17]   Awake replay of remote experiences in the hippocampus [J].
Karlsson, Mattias P. ;
Frank, Loren M. .
NATURE NEUROSCIENCE, 2009, 12 (07) :913-U132
[18]   Network Dynamics Underlying the Formation of Sparse, Informative Representations in the Hippocampus [J].
Karlsson, Mattias P. ;
Frank, Loren M. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (52) :14271-14281
[19]   Hippocampal Lesions Impair Rapid Learning of a Continuous Spatial Alternation Task [J].
Kim, Steve M. ;
Frank, Loren M. .
PLOS ONE, 2009, 4 (05)
[20]   Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory [J].
Nakashiba, Toshiaki ;
Buhl, Derek L. ;
McHugh, Thomas J. ;
Tonegawa, Susumu .
NEURON, 2009, 62 (06) :781-787
123