Pentoxifylline down modulate in vitro T cell responses and attenuate pathology in Leishmania and HTLV-1 infections

被引:18
作者
de Jesus, Amelia Ribeiro [1 ,2 ]
Luna, Tania [1 ]
de Almeida, Roque Pacheco [1 ,2 ]
Machado, Paulo Roberto Lima [1 ]
Carvalho, Edgar M. [1 ]
机构
[1] Univ Fed Bahia, Hosp Univ Prof Edgard Santos, Serv Imunol, BR-40110160 Salvador, BA, Brazil
[2] Univ Fed Sergipe, Dept Med, Aracaju, SE, Brazil
关键词
pentoxifylline; HTLV-1; leishmaniasis; cutaneous leishmaniasis; mucosal leishmaniasis; immunotherapy;
D O I
10.1016/j.intimp.2008.03.020
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tumor necrosis factor-alpha (TNF-alpha) is known to have numerous biological properties relating to inflammation. This cytokine participates in the tissue damage of chronic inflammatory, autoimmune and infectious diseases. Pentoxifylline is a methylxanthine that inhibits phosphodiesterase IV, which inhibits the degradation of the cAMP and prostanoids. The increased intracellular concentration of the cAMP leads to a negative regulation of NF-kappa B and NF-AT transcription factors and suppresses TNF-alpha production. This review describes studies that support evidences that TNF-alpha is involved in the pathogenesis of HTLV-1 associated myelopathy and of cutaneous and mucosal leishmaniasis. Additionally, it demonstrates the effect of pentoxifylline in vitro in inhibiting TNF-alpha. and IFN-gamma spontaneous production in PBMC from HTLV-1-infected patients, as well as its in vivo effect in inhibiting TNF-a in sera from mucosal leishmaniasis patients. Moreover, we review the results of clinical studies from the last 10 years using pentoxifylline to treat HTLV-1 associated myelopathy and cutaneous and mucosal leishmaniasis. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:1344 / 1353
页数:10
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