Surfacing role of probiotics in cancer prophylaxis and therapy: A systematic review

被引：49

作者：

Dasari, Subramanyam ^{[1
]}

Kathera, Chandrasekhar ^{[2
]}

Janardhan, Avilala ^{[3
]}

Kumar, Arthala Praveen ^{[4
]}

Viswanath, Buddolla ^{[5
]}

机构：

[1] Univ Illinois, Coll Med, Dept Biomed Sci, Rockford, IL 61107 USA

[2] Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

[3] Polytech Univ Madrid UPM, Ctr Biotechnol & Plant Genom CBGP, Dept Plant Biotechnol & Genom, Madrid 28040, Spain

[4] Sri Venkateswara Univ, Coll Sci, Dept Virol, Tirupati 517502, Andhra Pradesh, India

[5] Gachon Univ, Dept Bionanotechnol, San 65, Seongnam Si 461701, Gyeonggi Do, South Korea

来源：

CLINICAL NUTRITION | 2017年 / 36卷 / 06期

关键词：

Probiotics; Molecular mechanism; Cancer; Therapy; Immune response; LACTIC-ACID BACTERIA; CHAIN FATTY-ACIDS; BLOOD MONONUCLEAR-CELLS; NF-KAPPA-B; LACTOBACILLUS-CASEI; COLON-CANCER; HUMAN-ORIGIN; APOPTOSIS; ACIDOPHILUS; ACTIVATION;

D O I：

10.1016/j.clnu.2016.11.017

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Cancers figure among the most important causes of morbidity and mortality worldwide. Cancer and its associated infections are always complicated even when specific cancer regimens are available. It is well proved that Lactobacillus and other probiotic bacteria can modulate-ameliorate specific mechanisms against various infections including cancers. The present systematic review is intended to focus on the 'cellular and molecular mechanisms' of probiotic bacteria in the prevention and treatment of various cancers. The clinical and experimental findings of various studies explain the mechanisms such as apoptosis, antioxidant activity, immune response and epigenetics and illustrate the role of probiotics in cancer management and prophylaxis. In addition, the present review also discusses the safety aspects of probiotics when they are used in therapeutic and nutritional diet management. However, further investigations are required to reveal the effectiveness of probiotics in cancer treatment in clinical settings. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

引用

页码：1465 / 1472

页数：8

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