Targeted Photodynamic Killing of Breast Cancer Cells Employing Heptamannosylated β-Cyclodextrin-Mediated Nanoparticle Formation of an Adamantane-Functionalized BODIPY Photosensitizer

被引：69

作者：

Zhang, Quan ^{[1
,3
]}

Cai, Ying ^{[1
]}

Wang, Xiao-Jun ^{[2
]}

Xu, Jia-Long ^{[2
]}

Ye, Zhou ^{[1
,3
]}

Wang, Shengtao ^{[1
]}

Seeberger, Peter H. ^{[3
]}

Yin, Jian ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Peoples R China

[2] Jiangsu Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Peoples R China

[3] Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, D-14476 Potsdam, Germany

来源：

ACS APPLIED MATERIALS & INTERFACES | 2016年 / 8卷 / 49期

基金：

中国国家自然科学基金;

关键词：

BODIPY; mannose-mediated targeting photodynamic therapy; photosensitizer; supramolecular chemistry; MESOPOROUS SILICA NANOPARTICLES; IN-VIVO; DRUG-DELIVERY; EXCITED-STATE; SOLID TUMORS; THERAPY; MODULATION; GRAPHENE; VITRO;

D O I：

10.1021/acsami.6b13612

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The targeted delivery of a photosensitizer (PS) into specific cancer cells is an effective way to enhance the efficacy and minimize the side effects of photodynamic therapy. Herein, heptamannosylated beta-cydodextrin (beta-CD) was used to mediate the formation of an adamantane (Ad)-functionalized BODIPY PS nanoparticle via strong beta-CD/Ad complexation. The mannose-functionalized PS nanoparticles are selectively internalized by mannose-receptor-rich MDA-MB-231 breast cancer cells via receptor-mediated endocytosis, facilitating singlet oxygen generation to trigger apoptosis in cancer cells upon red-light irradiation. These nanoparticles exhibit excellent targeted delivery of the PS, leading to cancer cell death after irradiation both in vitro and in vivo.

引用

页码：33405 / 33411

页数：7

共 30 条

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