Molecular mechanisms for the anti-cancer effects of diallyl disulfide

被引：136
作者：
Yi, Lan [1 ]
Su, Qi [1 ]
机构：
[1] Univ South China, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 57卷
关键词：
Diallyl disulfide; Cell cycle; Apoptosis; Differentiation; Angiogenesis; Invasion; LEUKEMIA HL-60 CELLS; N-ACETYLTRANSFERASE ACTIVITY; COLON-CANCER CELLS; INCREASES HISTONE ACETYLATION; CASPASE-DEPENDENT APOPTOSIS; DADS-INDUCED APOPTOSIS; OCCURRING ORGANOSULFUR COMPOUNDS; DIFFERENTIALLY EXPRESSED GENES; P34(CDC2) KINASE-ACTIVITY; GARLIC SULFUR-COMPOUNDS;
D O I：
10.1016/j.fct.2013.04.001
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Considerable evidence in recent years suggests that garlic has anti-proliferative effects against various types of cancer. Garlic contains water-soluble and oil-soluble sulfur compounds. Oil-soluble compounds such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DAIS) and ajoene are more effective than water-soluble compounds in protection against cancer. DADS, a major organosulfur compound derived from garlic, can decrease carcinogen-induced cancers in experimental animals and inhibit the proliferation of various types of cancer cells. Its mechanisms of action include: the activation of metabolizing enzymes that detoxify carcinogens; suppression of the formation of DNA adducts; antioxidant effects; regulation of cell-cycle arrest; induction of apoptosis and differentiation; histone modification; and inhibition of angiogenesis and invasion. These topics are discussed in depth in this review. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
引用
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页码：362 / 370
页数：9
相关论文
共 138 条
[31]   Glutathione-related systems and modulation of extracellular signal-regulated kinases are involved in the resistance of AGS adenocarcinoma gastric cells to diallyl disulfide-induced apoptosis [J].
Filomeni, G ;
Aquilano, K ;
Rotilio, G ;
Ciriolo, MR .
CANCER RESEARCH, 2005, 65 (24) :11735-11742
[32]  
Filomeni G, 2003, CANCER RES, V63, P5940
[33]   Onion and garlic use and human cancer [J].
Galeone, Carlotta ;
Pelucchi, Claudio ;
Levi, Fabio ;
Negri, Eva ;
Franceschi, Silvia ;
Talamini, Renato ;
Giacosa, Attilio ;
La Vecchia, Carlo .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 84 (05) :1027-1032
[34]   Allium vegetables intake and endometrial cancer risk [J].
Galeone, Carlotta ;
Pelucchi, Claudio ;
Dal Maso, Luigino ;
Negri, Eva ;
Montella, Maurizio ;
Zucchetto, Antonella ;
Talamini, Renato ;
La Vecchia, Carlo .
PUBLIC HEALTH NUTRITION, 2009, 12 (09) :1576-1579
[35]   Effects of diallyl disulfide (DADS) on expression of apoptosis associated proteins in androgen independent human prostate cancer cells (PC-3) [J].
Gayathri, Ramachandran ;
Gunadharini, Dharmalingam Nandagopal ;
Arunkumar, Arumugam ;
Senthilkumar, Kalimuthu ;
Krishnamoorthy, Gunasekar ;
Banudevi, Sivanantham ;
Vignesh, Ramamoorthy Chandrakanth ;
Arunakaran, Jagadeesan .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2009, 320 (1-2) :197-203
[36]   Diet and cancer prevention: Where we are, where we are going [J].
Gonzalez, Carlos A. ;
Riboli, Elio .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2006, 56 (02) :225-231
[37]   Antiproliferative effect of diallyl disulfide (DADS) on prostate cancer cell line LNCaP [J].
Gunadharini, D. N. ;
Arunkumar, A. ;
Krishnamoorthy, G. ;
Muthuvel, R. ;
Vijayababu, M. R. ;
Kanagaraj, P. ;
Srinivasan, N. ;
Aruldhas, M. M. ;
Arunakaran, J. .
CELL BIOCHEMISTRY AND FUNCTION, 2006, 24 (05) :407-412
[38]   Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis [J].
Guyonnet, D ;
Bergès, R ;
Siess, MH ;
Pinnert, MF ;
Chagnon, MC ;
Suschetet, M ;
Le Bon, AM .
FOOD AND CHEMICAL TOXICOLOGY, 2004, 42 (09) :1479-1485
[39]   Mechanisms of protection against aflatoxin B1 genotoxicity in rats treated by organosulfur compounds from garlic [J].
Guyonnet, D ;
Belloir, C ;
Suschetet, M ;
Siess, MH ;
Le Bon, AM .
CARCINOGENESIS, 2002, 23 (08) :1335-1341
[40]   Inhibition of aflatoxin B-1- and N-nitrosodiethylamine-induced liver preneoplastic foci in rats fed naturally occurring allyl sulfides [J].
HaberMignard, D ;
Suschetet, M ;
Berges, R ;
Astorg, P ;
Siess, MH .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1996, 25 (01) :61-70
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