Molecular mechanisms for the anti-cancer effects of diallyl disulfide

被引：130
作者：
Yi, Lan [1 ]
Su, Qi [1 ]
机构：
[1] Univ South China, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 57卷
关键词：
Diallyl disulfide; Cell cycle; Apoptosis; Differentiation; Angiogenesis; Invasion; LEUKEMIA HL-60 CELLS; N-ACETYLTRANSFERASE ACTIVITY; COLON-CANCER CELLS; INCREASES HISTONE ACETYLATION; CASPASE-DEPENDENT APOPTOSIS; DADS-INDUCED APOPTOSIS; OCCURRING ORGANOSULFUR COMPOUNDS; DIFFERENTIALLY EXPRESSED GENES; P34(CDC2) KINASE-ACTIVITY; GARLIC SULFUR-COMPOUNDS;
D O I：
10.1016/j.fct.2013.04.001
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Considerable evidence in recent years suggests that garlic has anti-proliferative effects against various types of cancer. Garlic contains water-soluble and oil-soluble sulfur compounds. Oil-soluble compounds such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DAIS) and ajoene are more effective than water-soluble compounds in protection against cancer. DADS, a major organosulfur compound derived from garlic, can decrease carcinogen-induced cancers in experimental animals and inhibit the proliferation of various types of cancer cells. Its mechanisms of action include: the activation of metabolizing enzymes that detoxify carcinogens; suppression of the formation of DNA adducts; antioxidant effects; regulation of cell-cycle arrest; induction of apoptosis and differentiation; histone modification; and inhibition of angiogenesis and invasion. These topics are discussed in depth in this review. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
引用
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页码：362 / 370
页数：9
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