DBU-promoted tandem Michael-addition/cyclization for the synthesis of polysubstituted pyrroles

被引：11

作者：

Yang, Tianyu ^{[1
]}

Wang, Ke-Hu ^{[1
]}

Huang, Danfeng ^{[1
]}

Li, Pengfei ^{[1
]}

Deng, Zhoubin ^{[1
]}

Su, Yinpeng ^{[1
]}

Hu, Yulai ^{[1
,2
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

TETRAHEDRON | 2019年 / 75卷 / 15期

基金：

中国国家自然科学基金;

关键词：

alpha; beta-unsaturated ynones; Glycine ethyl ester; Pyrroles; Michael addition; Cyclization; Tandem reaction; EFFICIENT SYNTHESIS; BIOLOGICAL EVALUATION; ACETYLENIC KETONES; CONVENIENT METHOD; FLOW SYNTHESIS; DERIVATIVES; COPPER; CYCLOISOMERIZATION; DIMERIZATION; CYCLIZATION;

D O I：

10.1016/j.tet.2019.02.057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and transition-metal-free method for the synthesis of the structurally diversified pyrroles is described. Various alpha,beta-unsaturated ynones reacted with N-substituted ethyl glycine ethyl ester hydro-chlorides in the presence of DBU to form the corresponding products in good yields. This protocol has the advantages of readily available starting materials, mild reaction conditions and a wide scope of substrates, which provides a practical route for the synthesis of polysubstituted pyrroles. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：2291 / 2297

页数：7

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