Diagnosis of breast cancer based on breath analysis: An emerging method

Breast cancer (BC) is the most commonly diagnosed malignancy and the second leading cause of the cancer-related deaths among females. Early diagnosis is one of the most important strategies to reduce breast cancer morbidity rate and improve the survival rate. However, early diagnosis of breast cancer is limited because the disease usually develops asymptomatically. Moreover, current screening techniques for breast cancer are always expensive, discomfort, and even harmful for patients, and furthermore, do not fulfill the requirements for reliable differentiation between breast cancer patients and healthy subjects. Breath analysis is non-invasive, painless, easy to perform and no risk to patients. Therefore, this innovative method provides a potentially useful approach to screen breast cancer. This review summarizes the scientific evidences related to breast cancer patients through detecting unique potential biomarkers in the exhaled breath, and the profile of breath biomarker for breast cancer clinical diagnosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.