Enhanced induction of Cyp24a1 by FGF23 but low serum 24,25-dihydroxyvitamin D in CKD: implications for therapy

被引：7

作者：

Dusso, Adriana S. ^{[1
]}

Rodriguez, Mariano ^{[2
]}

机构：

[1] Univ Lleida, Lleida Sch Med, IRBLleida Lleida Inst Biomed Res, Expt Nephrol Lab, Lleida, Spain

[2] Univ Cordoba, Dept Med, Hosp Reina Sofia, Nephrol Serv,Res Unit, Cordoba, Spain

来源：

KIDNEY INTERNATIONAL | 2012年 / 82卷 / 10期

关键词：

VITAMIN-D; CATABOLISM;

D O I：

10.1038/ki.2012.273

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In normal people, induction by FGF23 of renal Cyp24a1, the enzyme that degrades 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, helps to protect from the disorders caused by excessive 1,25-dihydroxyvitamin D. Dai and co-workers report, however, that in human and mouse kidney disease, high FGF23 concurs with low rather than high serum 24,25-dihydroxyvitamin D, a biomarker of Cyp24a1 activity. Their characterization of the underlying mechanisms provides new understanding of how kidney disease impairs the health benefits of vitamin D-FGF23/klotho interactions.

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收藏

页码：1046 / 1049

页数：4

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