Heme/Copper Assembly Mediated Nitrite and Nitric Oxide Interconversion

被引：52

作者：

Hematian, Shabnam ^{[1
]}

Siegler, Maxime A. ^{[1
]}

Karlin, Kenneth D. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 46期

基金：

美国国家卫生研究院;

关键词：

CYTOCHROME-C-OXIDASE; MOLECULAR-MECHANISMS; HEME; COMPLEX; NO; MODEL; REDUCTASE; BINDING; TETRAKIS(2,6-DIFLUOROPHENYL)PORPHYRINATE(2-); CERULOPLASMIN;

D O I：

10.1021/ja3083818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The heme(a3)/Cu-B active site of cytochrome c oxidase is responsible for cellular nitrite reduction to nitric oxide; the same center can return NO to the nitrite pool via oxidative chemistry Here, we show that a partially reduced heme/Cu assembly reduces NO2- ion, producing nitric oxide. The heme serves as the reductant, but the Cu-II ion is also required. In turn, a mu-oxo heme-Fe-III-O-Cu-II complex facilitates NO oxidation to nitrite; the final products are the reduced heme and Cu-II-nitrito complexes.

引用

页码：18912 / 18915

页数：4

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