NMR reaction monitoring during the development of an active pharmaceutical ingredient

被引：18

作者：

Clegg, Ian M. ^{[2
]}

Gordon, Charles M. ^{[1
]}

Smith, David S. ^{[2
]}

Alzaga, Roberto ^{[2
]}

Codina, Anna ^{[2
]}

机构：

[1] Pfizer R&D, Chem Res & Dev, Sandwich CT13 9NJ, Kent, England

[2] Pfizer R&D, Analyt Dev, Sandwich CT13 9NJ, Kent, England

来源：

ANALYTICAL METHODS | 2012年 / 4卷 / 06期

关键词：

HYDROGEN-BONDS; SPECTROSCOPY; KINETICS;

D O I：

10.1039/c1ay05384a

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We show the use of NMR spectroscopy to develop detailed understanding of a reaction mechanism during development of a manufacturing process for an active pharmaceutical ingredient (API). This includes structural elucidation of reaction starting materials, intermediates and products. The method is able to generate an immediate mass balance through quantitative profiling of all materials involved in the reaction. A straightforward reaction monitoring methodology was employed using existing laboratory based equipment.

引用

页码：1498 / 1506

页数：9

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