Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine

被引：141

作者：

Medvedev, S. P. ^{[1
]}

Shevchenko, A. I. ^{[1
]}

Zakian, S. M. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Moscow 117901, Russia

[2] Russian Acad Med Sci, Siberian Branch, Res Ctr Clin & Expt Med, Moscow 109801, Russia

来源：

ACTA NATURAE | 2010年 / 2卷 / 02期

关键词：

cell reprogramming; induced pluripotent stem cells; directed stem cell differentiation; cell replacement therapy; HUMAN SOMATIC-CELLS; IPS CELLS; HUMAN FIBROBLASTS; DIRECTED DIFFERENTIATION; DEFINED FACTORS; IN-VITRO; C-MYC; GENERATION; MOUSE; INDUCTION;

D O I：

10.32607/20758251-2010-2-2-18-27

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induced pluripotent stem cells (iPSCs) are a new type of pluripotent cells that can be obtained by reprogramming animal and human differentiated cells. In this review, issues related to the nature of iPSCs are discussed and different methods of iPSC production are described. We particularly focused on methods of iPSC production without the genetic modification of the cell genome and with means for increasing the iPSC production efficiency. The possibility and issues related to the safety of iPSC use in cell replacement therapy of human diseases and a study of new medicines are considered.

引用

页码：18 / 27

页数：10

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