Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine

被引：141

作者：

Medvedev, S. P. ^{[1
]}

Shevchenko, A. I. ^{[1
]}

Zakian, S. M. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Moscow 117901, Russia

[2] Russian Acad Med Sci, Siberian Branch, Res Ctr Clin & Expt Med, Moscow 109801, Russia

来源：

ACTA NATURAE | 2010年 / 2卷 / 02期

关键词：

cell reprogramming; induced pluripotent stem cells; directed stem cell differentiation; cell replacement therapy; HUMAN SOMATIC-CELLS; IPS CELLS; HUMAN FIBROBLASTS; DIRECTED DIFFERENTIATION; DEFINED FACTORS; IN-VITRO; C-MYC; GENERATION; MOUSE; INDUCTION;

D O I：

10.32607/20758251-2010-2-2-18-27

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induced pluripotent stem cells (iPSCs) are a new type of pluripotent cells that can be obtained by reprogramming animal and human differentiated cells. In this review, issues related to the nature of iPSCs are discussed and different methods of iPSC production are described. We particularly focused on methods of iPSC production without the genetic modification of the cell genome and with means for increasing the iPSC production efficiency. The possibility and issues related to the safety of iPSC use in cell replacement therapy of human diseases and a study of new medicines are considered.

引用

页码：18 / 27

页数：10

共 94 条

[1] Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes [J].

Aasen, Trond ;

Raya, Angel ;

Barrero, Maria J. ;

Garreta, Elena ;

Consiglio, Antonella ;

Gonzalez, Federico ;

Vassena, Rita ;

Bilic, Josipa ;

Pekarik, Vladimir ;

Tiscornia, Gustavo ;

Edel, Michael ;

Boue, Stephanie ;

Izpisua Belmonte, Juan Carlos .

NATURE BIOTECHNOLOGY, 2008, 26 (11) :1276-1284

[2] Generation of pluripotent stem cells from adult mouse liver and stomach cells [J].

Aoi, Takashi ;

Yae, Kojiro ;

Nakagawa, Masato ;

Ichisaka, Tomoko ;

Okita, Keisuke ;

Takahashi, Kazutoshi ;

Chiba, Tsutomu ;

Yamanaka, Shinya .

SCIENCE, 2008, 321 (5889) :699-702

[3] An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors [J].

Ben-Porath, Ittai ;

Thomson, Matthew W. ;

Carey, Vincent J. ;

Ge, Ruping ;

Bell, George W. ;

Regev, Aviv ;

Weinberg, Robert A. .

NATURE GENETICS, 2008, 40 (05) :499-507

[4] Core transcriptional regulatory circuitry in human embryonic stem cells [J].

Boyer, LA ;

Lee, TI ;

Cole, MF ;

Johnstone, SE ;

Levine, SS ;

Zucker, JR ;

Guenther, MG ;

Kumar, RM ;

Murray, HL ;

Jenner, RG ;

Gifford, DK ;

Melton, DA ;

Jaenisch, R ;

Young, RA .

CELL, 2005, 122 (06) :947-956

[5] Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells [J].

Buchholz, David E. ;

Hikita, Sherry T. ;

Rowland, Teisha J. ;

Friedrich, Amy M. ;

Hinman, Cassidy R. ;

Johnson, Lincoln V. ;

Clegg, Dennis O. .

STEM CELLS, 2009, 27 (10) :2427-2434

[6] Reprogramming of murine and human somatic cells using a single polycistronic vector [J].

Carey, Bryce W. ;

Markoulaki, Styliani ;

Hanna, Jacob ;

Saha, Kris ;

Gao, Qing ;

Mitalipova, Maisam ;

Jaenisch, Rudolf .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (01) :157-162

[7] Protective Effects of Human iPS-Derived Retinal Pigment Epithelium Cell Transplantation in the Retinal Dystrophic Rat [J].

Carr, Amanda-Jayne ;

Vugler, Anthony A. ;

Hikita, Sherry T. ;

Lawrence, Jean M. ;

Gias, Carlos ;

Chen, Li Li ;

Buchholz, David E. ;

Ahmado, Ahmad ;

Semo, Ma'ayan ;

Smart, Matthew J. K. ;

Hasan, Shazeen ;

da Cruz, Lyndon ;

Johnson, Lincoln V. ;

Clegg, Dennis O. ;

Coffey, Pete J. .

PLOS ONE, 2009, 4 (12)

[8] Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling [J].

Chambers, Stuart M. ;

Fasano, Christopher A. ;

Papapetrou, Eirini P. ;

Tomishima, Mark ;

Sadelain, Michel ;

Studer, Lorenz .

NATURE BIOTECHNOLOGY, 2009, 27 (03) :275-280

[9] Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells [J].

Choi, Kyung-Dal ;

Yu, Junying ;

Smuga-Otto, Kim ;

Salvagiotto, Giorgia ;

Rehrauer, William ;

Vodyanik, Maxim ;

Thomson, James ;

Slukvin, Igor .

STEM CELLS, 2009, 27 (03) :559-567

[10] Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 [J].

Danwei Huangfu ;

Osafune, Kenji ;

Maehr, Rene ;

Guo, Wenjun ;

Eijkelenboom, Astrid ;

Chen, Shuibing ;

Muhlestein, Whitney ;

Melton, Douglas A. .

NATURE BIOTECHNOLOGY, 2008, 26 (11) :1269-1275

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