STEM CELL PLASTICITY Plasticity of epithelial stem cells in tissue regeneration

被引：449

作者：

Blanpain, Cedric ^{[1
,2
]}

Fuchs, Elaine ^{[3
]}

机构：

[1] Univ Libre Bruxelles, IRIBHM, B-1070 Brussels, Belgium

[2] Univ Libre Bruxelles, Walloon Excellence Life Sci & Biotechnol WELBIO, B-1070 Brussels, Belgium

[3] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA

来源：

SCIENCE | 2014年 / 344卷 / 6189期

基金：

欧洲研究理事会;

关键词：

HAIR-FOLLICLE REGENERATION; TRANSIT-AMPLIFYING CELLS; LABEL-RETAINING CELLS; PROGENITOR CELLS; PROSTATE-CANCER; SMALL-INTESTINE; MAMMARY-GLAND; IN-VITRO; SELF-RENEWAL; WOUND REPAIR;

D O I：

10.1126/science.1242281

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tissues rely upon stem cells for homeostasis and repair. Recent studies show that the fate and multilineage potential of epithelial stem cells can change depending on whether a stem cell exists within its resident niche and responds to normal tissue homeostasis, whether it is mobilized to repair a wound, or whether it is taken from its niche and challenged to de novo tissue morphogenesis after transplantation. In this Review, we discuss how different populations of naturally lineage-restricted stem cells and committed progenitors can display remarkable plasticity and reversibility and reacquire long-term self-renewing capacities and multilineage differentiation potential during physiological and regenerative conditions. We also discuss the implications of cellular plasticity for regenerative medicine and for cancer.

引用

页码：1243 / +

页数：11

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