STEM CELL PLASTICITY Plasticity of epithelial stem cells in tissue regeneration

被引：445
作者：
Blanpain, Cedric [1 ,2 ]
Fuchs, Elaine [3 ]
机构：
[1] Univ Libre Bruxelles, IRIBHM, B-1070 Brussels, Belgium
[2] Univ Libre Bruxelles, Walloon Excellence Life Sci & Biotechnol WELBIO, B-1070 Brussels, Belgium
[3] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA
来源：
SCIENCE | 2014年 / 344卷 / 6189期
基金：
欧洲研究理事会;
关键词：
HAIR-FOLLICLE REGENERATION; TRANSIT-AMPLIFYING CELLS; LABEL-RETAINING CELLS; PROGENITOR CELLS; PROSTATE-CANCER; SMALL-INTESTINE; MAMMARY-GLAND; IN-VITRO; SELF-RENEWAL; WOUND REPAIR;
D O I：
10.1126/science.1242281
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Tissues rely upon stem cells for homeostasis and repair. Recent studies show that the fate and multilineage potential of epithelial stem cells can change depending on whether a stem cell exists within its resident niche and responds to normal tissue homeostasis, whether it is mobilized to repair a wound, or whether it is taken from its niche and challenged to de novo tissue morphogenesis after transplantation. In this Review, we discuss how different populations of naturally lineage-restricted stem cells and committed progenitors can display remarkable plasticity and reversibility and reacquire long-term self-renewing capacities and multilineage differentiation potential during physiological and regenerative conditions. We also discuss the implications of cellular plasticity for regenerative medicine and for cancer.
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收藏
页码：1243 / +
页数：11
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