Frontiers in non-union research

被引：16

作者：

Gomez-Barrena, Enrique ^{[1
]}

Padilla-Eguiluz, Norma G. ^{[1
]}

Rosset, Philippe ^{[2
]}

机构：

[1] Univ Autonoma Madrid, Hosp La Paz IdiPAZ, Serv Cirugia Ortoped & Traumat, Madrid, Spain

[2] Univ Tours, CHU Tours, Serv Chirurg Orthoped & Traumatol, Tours, France

来源：

EFORT OPEN REVIEWS | 2020年 / 5卷 / 10期

基金：

欧盟地平线“2020”;

关键词：

ATMPs (advanced therapy medicinal products); bone healing; cell therapy; MSCs (mesenchymal stromal cells) and biomaterials; non-union; RADIOGRAPHIC UNION SCORE; MESENCHYMAL STEM-CELLS; BONE-MARROW GRAFT; OPEN FRACTURES; TIBIAL FRACTURES; MANAGEMENT; DEFECTS; SHAFT; REGENERATION; NAILS;

D O I：

10.1302/2058-5241.5.190062

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing. Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products. Basic science and research on non-union treatments is needed to compile preclinical data on new treatments. Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment. Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products.

引用

页码：574 / 583

页数：10

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