Non-Coding RNAs and Cancer

被引：42
作者：
Calore, Federica [1 ]
Lovat, Francesca [1 ]
Garofalo, Michela [1 ]
机构：
[1] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 08期
关键词：
small non-coding RNAs; long non-coding RNAs; cancer; NATURAL ANTISENSE TRANSCRIPT; PIWI-INTERACTING RNAS; SMALL-NUCLEOLAR RNAS; TUMOR-SUPPRESSOR; DOWN-REGULATION; GROWTH-ARREST; LUNG-CANCER; PROSTATE-CANCER; GENE-EXPRESSION; HEPATOCELLULAR-CARCINOMA;
D O I：
10.3390/ijms140817085
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The discovery of the biological relevance of non-coding RNA (ncRNAs) molecules represents one of the most significant advances in contemporary molecular biology. Expression profiling of human tumors, based on the expression of miRNAs and other short or long ncRNAs, has identified signatures associated with diagnosis, staging, progression, prognosis, and response to treatment. In this review we will discuss the recent remarkable advancement in the understanding the biological functions of human ncRNAs in cancer, the mechanisms of expression and the therapeutic potential.
引用
收藏
页码：17085 / 17110
页数：26
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