Epigenetic mechanisms of drug addiction

被引：73

作者：

Feng, Jian

Nestler, Eric J. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Fishberg Dept Neurosci, New York, NY 10029 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2013年 / 23卷 / 04期

关键词：

DNA METHYLATION; NONCODING RNAS; NUCLEUS-ACCUMBENS; COCAINE INTAKE; EXPRESSION; PLASTICITY; CHROMATIN; 5-METHYLCYTOSINE; GENE; SEQ;

D O I：

10.1016/j.conb.2013.01.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epigenetic regulation can mediate long-lasting changes in gene expression, which makes it an attractive mechanism for the stable behavioral abnormalities that characterize drug addiction. Recent research has unveiled numerous types of epigenetic modifications within the brain's reward circuitry in animal models of drug addiction. In this review, we summarize the latest advances in the field, focusing on histone modifications, DNA methylation, and noncoding RNAs. We also highlight several areas for future research. Unraveling the highly complex epigenetic mechanisms of addiction is adding to our understanding of this syndrome and has the potential to trigger novel approaches for better diagnosis and therapy.

引用

收藏

页码：521 / 528

页数：8

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