The role of bone marrow biopsy examination at diagnosis of chronic lymphocytic leukemia: a reappraisal

被引：4

作者：

Baliakas, Panagiotis ^{[1
,2
]}

Kanellis, George ^{[3
]}

Stavroyianni, Niki ^{[1
,2
]}

Fameli, Maria ^{[3
]}

Anagnostopoulos, Achilles ^{[1
,2
]}

Stamatopoulos, Kostas ^{[1
,2
,4
]}

Papadaki, Theodora ^{[3
]}

机构：

[1] G Papanicolaou Hosp, Dept Hematol, Thessaloniki 57010, Greece

[2] G Papanicolaou Hosp, HCT Unit, Thessaloniki 57010, Greece

[3] Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece

[4] Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece

来源：

LEUKEMIA & LYMPHOMA | 2013年 / 54卷 / 11期

关键词：

CLL; bone marrow biopsy; immunohistochemistry; autoimmunity; chronic lymphocytic leukemia; IDENTIFIES RECURRENT MUTATIONS; HAIRY-CELL LEUKEMIA; CLINICAL-SIGNIFICANCE; PROGNOSTIC MARKERS; HODGKINS-DISEASE; STERNBERG CELLS; LYMPHOMA; TRISOMY-12; RECEPTORS; ANTIGEN;

D O I：

10.3109/10428194.2013.780653

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

According to the International Workshop on Chronic Lymphocytic Leukemia/National Institutes of Health (iwCLL/NIH) guidelines for the diagnosis and treatment of chronic lymphocytic leukemia (CLL), bone marrow biopsy (BMB) is not required at diagnosis, however recommended before initiating treatment. That notwithstanding, histopathological examination of the BMB has the potential to provide important information of both clinical and biological significance. Here we attempt a reappraisal of the role of BMB examination in the modern diagnostic work-up of patients with CLL, based on both the literature and our accumulated experience from the systematic and multiparametric evaluation of a large series of BMB samples taken at diagnosis of CLL. Overall, we argue that the study of BMB offers important information not only for diagnostic purposes but also for elucidating CLL pathobiology.

引用

页码：2377 / 2384

页数：8

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