Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas

被引：190
作者：
Kahlert, U. D. [1 ]
Nikkhah, G. [1 ]
Maciaczyk, J. [2 ]
机构：
[1] Univ Med Ctr Freiburg, Dept Gen Neurosurg, Sect Stereotact Neurosurg, Freiburg, Germany
[2] Univ Med Ctr Freiburg, Dept Gen Neurosurg, Freiburg, Germany
来源：
CANCER LETTERS | 2013年 / 331卷 / 02期
关键词：
EMT; GBM; Cancer stem cell; Invasiveness; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER STEM-CELLS; GROWTH-FACTOR RECEPTOR; BREAST-CANCER; GLIOBLASTOMA CELLS; COLORECTAL-CANCER; TUMOR PROGRESSION; INHIBITS GROWTH; BRAIN-TUMORS; BETA-CATENIN;
D O I：
10.1016/j.canlet.2012.12.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor dissemination and metastatic behavior account for the vast majority of cancer associated mortality. Epithelial tumors achieve this progressive state via epithelial-to-mesenchymal transition (EMT); however, the importance of this process in the neuroepithelial context is currently very controversially discussed. The review describes the current research status concerning EMT-like changes in malignant gliomas including the role of TWIST1, ZEB1/ZEB2 and SNAIl1/SNAIl2 as inducers for cell-invasiveness in GBMs. Furthermore, WNT/beta-catenin signaling with its key-component FRIZZLED4 activating an EMT-like program in malignant gliomas and its relationship to the stem-like phenotype as well as discoveries on micro-RNA-level regulating the EMT-like process are discussed. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：131 / 138
页数：8
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