Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas

被引：190

作者：

Kahlert, U. D. ^{[1
]}

Nikkhah, G. ^{[1
]}

Maciaczyk, J. ^{[2
]}

机构：

[1] Univ Med Ctr Freiburg, Dept Gen Neurosurg, Sect Stereotact Neurosurg, Freiburg, Germany

[2] Univ Med Ctr Freiburg, Dept Gen Neurosurg, Freiburg, Germany

来源：

CANCER LETTERS | 2013年 / 331卷 / 02期

关键词：

EMT; GBM; Cancer stem cell; Invasiveness; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER STEM-CELLS; GROWTH-FACTOR RECEPTOR; BREAST-CANCER; GLIOBLASTOMA CELLS; COLORECTAL-CANCER; TUMOR PROGRESSION; INHIBITS GROWTH; BRAIN-TUMORS; BETA-CATENIN;

D O I：

10.1016/j.canlet.2012.12.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor dissemination and metastatic behavior account for the vast majority of cancer associated mortality. Epithelial tumors achieve this progressive state via epithelial-to-mesenchymal transition (EMT); however, the importance of this process in the neuroepithelial context is currently very controversially discussed. The review describes the current research status concerning EMT-like changes in malignant gliomas including the role of TWIST1, ZEB1/ZEB2 and SNAIl1/SNAIl2 as inducers for cell-invasiveness in GBMs. Furthermore, WNT/beta-catenin signaling with its key-component FRIZZLED4 activating an EMT-like program in malignant gliomas and its relationship to the stem-like phenotype as well as discoveries on micro-RNA-level regulating the EMT-like process are discussed. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：131 / 138

页数：8

共 122 条

[1] miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy [J].

Adam, Liana ;

Zhong, Meng ;

Choi, Woonyoung ;

Qi, Wei ;

Nicoloso, Milena ;

Arora, Ameeta ;

Calin, George ;

Wang, Hua ;

Siefker-Radtke, Arlene ;

McConkey, David ;

Bar-Eli, Menashe ;

Dinney, Colin .

CLINICAL CANCER RESEARCH, 2009, 15 (16) :5060-5072

[2] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[3] Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma [J].

Angeles Castilla, Maria ;

Moreno-Bueno, Gema ;

Romero-Perez, Laura ;

Van De Vijver, Koen ;

Biscuola, Michele ;

Angeles Lopez-Garcia, Maria ;

Prat, Jaime ;

Matias-Guiu, Xavier ;

Cano, Amparo ;

Oliva, Esther ;

Palacios, Jose .

JOURNAL OF PATHOLOGY, 2011, 223 (01) :72-80

[4] Notch Signaling Promotes Growth and Invasion in Uveal Melanoma [J].

Asnaghi, Laura ;

Ebrahimi, Katayoon B. ;

Schreck, Karisa C. ;

Bar, Eli E. ;

Coonfield, Michael L. ;

Bell, W. Robert ;

Handa, James ;

Merbs, Shannath L. ;

Harbour, J. William ;

Eberhart, Charles G. .

CLINICAL CANCER RESEARCH, 2012, 18 (03) :654-665

[5] RETRACTED: Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells (Retracted article. See vol. 423, pg. 153, 2018) [J].

Bao, Bin ;

Wang, Zhiwei ;

Ali, Shadan ;

Kong, Dejuan ;

Li, Yiwei ;

Ahmad, Aamir ;

Banerjee, Sanjeev ;

Azmi, Asfar S. ;

Miele, Lucio ;

Sarkar, Fazlul H. .

CANCER LETTERS, 2011, 307 (01) :26-36

[6] Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[7] Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma [J].

Bar, Eli E. ;

Chaudhry, Aneeka ;

Lin, Alex ;

Fan, Xing ;

Schreck, Karisa ;

Matsui, William ;

Piccirillo, Sara ;

Vescovi, Angelo L. ;

DiMeco, Francesco ;

Olivi, Alessandro ;

Eberharta, Charles G. .

STEM CELLS, 2007, 25 (10) :2524-2533

[8] Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres [J].

Bar, Eli E. ;

Lin, Alex ;

Mahairaki, Vasiliki ;

Matsui, William ;

Eberhart, Charles G. .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (03) :1491-1502

[9] SLUG/SNAI2 and Tumor Necrosis Factor Generate Breast Cells With CD44+/CD24-Phenotype [J].

Bhat-Nakshatri, Poornima ;

Appaiah, Hitesh ;

Ballas, Christopher ;

Pick-Franke, Patricia ;

Goulet, Robert, Jr. ;

Badve, Sunil ;

Srour, Edward F. ;

Nakshatri, Harikrishna .

BMC CANCER, 2010, 10

[10]

Bleau AM, 2009, CELL CYCLE, V8, P2936

← 1 2 3 4 5 6 7 8 9 10 →