Synthesis of 2-Oxindoles from Substituted Indoles by Hypervalent-Iodine Oxidation

被引：46

作者：

Jiang, Xinpeng ^{[1
]}

Zheng, Cong ^{[1
]}

Lei, Lijun ^{[1
]}

Lin, Kai ^{[1
]}

Yu, Chuanming ^{[1
,2
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou, Zhejiang, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Nitrogen heterocycles; Hypervalent compounds; Iodine; Indoles; Oxidation; ONE-POT SYNTHESIS; KINASE INHIBITORS; DESIGN; REAGENTS; DERIVATIVES; ASSIGNMENT; DISCOVERY; OXINDOLES;

D O I：

10.1002/ejoc.201701807

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical conversion of indoles into the corresponding 2-oxindoles is achieved efficiently using a hypervalent iodine reagent. This oxidation is amenable to different substituted indoles, and allows the synthesis of a wide range of synthetically valuable substituted 2-oxindoles in up to 90% yield. Furthermore, Ropinirole, a drug used to alleviate the symptoms of Parkinson's disease, was synthesized in three steps in an overall yield of 44% using this method.

引用

页码：1437 / 1442

页数：6

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