Synthesis and biological evaluation of nitric oxide (NO)-hydrogen sulfide (H2S) releasing derivatives of (S)-3-n-butylphthalide as potential antiplatelet agents

被引：0

作者：

Wang Xiao-Li ^{[1
]}

Wang Zhao-Ya ^{[1
]}

Ling Jing-Jing ^{[2
]}

Zhang Yi-Hua ^{[3
]}

Yin Jian ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Peoples R China

[2] Wuxi Peoples Hosp, Wuxi 214023, Peoples R China

[3] China Pharmaceut Univ, Inst Pharmaceut Sci, Nanjing 210009, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2016年 / 14卷 / 12期

关键词：

(S)-3-n-butylphthalide; Nitric oxide; Hydrogen sulfide; Antiplatelet agents; CEREBRAL-BLOOD-FLOW; HYDROGEN-SULFIDE; 2-(1-HYDROXYPENTYL)-BENZOATE; 3-N-BUTYLPHTHALIDE; PEROXYNITRITE; MODEL;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of (S)-3-n-butylphthalide ((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-NBP-5 displayed the strongest activity in inhibiting the arachidonic acid (AA)-and adenosine diphosphate (ADP)-induced platelet aggregation in vitro, with 3.8-and 7.0-fold more effectiveness than (S)-NBP, respectively. Furthermore, NOSH-NBP-5 could release moderate levels of NO and H2S, which would be beneficial in improving cardiovascular and cerebral circulation. Moreover, NOSH-NBP-5 could release (S)-NBP when incubated with rat brain homogenate. In conclusion, these findings may provide new insights into the development of novel antiplatelet agents for the treatment of thrombosis-related ischemic stroke.

引用

页码：946 / 953

页数：8

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