Scleroderma, D-penicillamine treatment, and progressive renal failure associated with positive antimyeloperoxidase antineutrophil cytoplasmic antibodies

Progressive renal failure in patients with scleroderma is a sinister development that is usually attributed to impaired renal blood flow, In some exceptional cases, the underlying pathology is a crescentic glomerulonephritis, which has been associated with positive antineutrophil cytoplasmic antibodies, and in particular antimyeloperoxidase antibodies, The prognosis in such cases has been very poor, We report such a patient whose renal function has improved and stabilized on immunosuppressive therapy. (C) 1997 by the National Kidney Foundation, Inc.