Acute stress show great influences on liver function and the expression of hepatic genes associated with lipid metabolism in rats

被引：19

作者：

Gao, Xiaoling ^{[1
]}

Zeng, Yuaner ^{[1
]}

Liu, Shuqiang ^{[1
]}

Wang, Shuling ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Sch Chinese Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China

来源：

LIPIDS IN HEALTH AND DISEASE | 2013年 / 12卷

基金：

中国国家自然科学基金;

关键词：

Acute stress; Lipid metabolism; Raged impairing liver; Scavenger receptor BI; ATP-binding cassette transporter; OXIDATIVE STRESS; CHOLESTEROL; RECEPTOR; EXTRACT;

D O I：

10.1186/1476-511X-12-118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: The theory of Chinese medicine believes rage harms normal liver function, namely 'raged impairing liver' in short. The purpose of this study is to investigate the impact of acute stress on liver lipid metabolism in rats. Methods and results: Comparison of liver function indicators, serum lipid level of rats under acute stress and normal rats, as well as detection of liver tissue in the SR - BI, ABCG5 and ABCG8 protein and gene expression changes. Acute stressed rats had shown a lower serum levels of albumin (P<0.01), HDL-cholesterol (P<0.01) than normal rats, with higher serum levels of globulin (P<0.01) and LDL-cholesterol (P<0.05). Acute stressed rat's liver tissue exhibited a lower protein expression of ABCG5 (P<0.05), ABCG8 (P<0.01) and a higher level of SR-BI (P<0.05), compared with to normal rats. Furthermore, liver gene expression of ABCG5 (P<0.01) and ABCG8 (P<0.05) were lower in acute stressed rats than in normal rats, while SR-BI was higher in acute stressed rats than in normal rats (P<0.01). Conclusions: Acute stress had a direct influence on rat's liver lipid metabolism.

引用

页数：6

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