Synthesis of novel glycosyl 1,3,4-thiadiazole derivatives

被引：4

作者：

Cheng, Feng-Chang ^{[2
]}

Yin, Long ^{[1
]}

Liu, Xiu-Jian ^{[1
]}

Liu, Wei-Wei ^{[1
,3
,4
]}

Cao, Zhi-Ling ^{[1
,3
]}

Shi, Da-Hua ^{[1
,3
]}

Wang, Lei ^{[1
]}

机构：

[1] Huaihai Inst Technol, Coll Pharmaceut Sci, Lianyungang 222005, Peoples R China

[2] China Univ Min & Technol, Xuzhou 221116, Peoples R China

[3] Jiangsu Inst Marine Resources, Lianyungang 222005, Peoples R China

[4] Huaihai Inst Technol, Jiangsu Key Lab Marine Pharmaceut Compound Screen, Lianyungang 222005, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2016年 / 10期

关键词：

D-glucosamine; 1,3,4-thiadiazole; glycosyl isothiocyanate; GLUCOSAMINE HYDROCHLORIDE; CELLS;

D O I：

10.3184/174751916X14738636315471

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient and mild protocol for the synthesis of glycosyl 1,3,4-thiadiazole derivatives was developed, which involved the reaction of glycosyl isothiocyanate, hydrazine hydrate, and various aldehydes followed by oxidative cyclisation with ferric ammonium sulfate in methanol. 13 examples of different glycosyl 1,3,4-thiadiazole derivatives were prepared. Good yields (70-87%) have been achieved. The glycosyl 1,3,4-thiadiazole derivatives may find applications in medicinal chemistry and pharmaceutical industry.

引用

页码：614 / 619

页数：6

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