Synthesis of 1H-Indole-2,3-dicarboxylates via Rhodium-Catalyzed C-H Annulation of Arylhydrazines with Maleates

被引：5

作者：

Zhang, Sheng ^{[1
]}

Li, He ^{[2
]}

Yamamoto, Yoshinori ^{[1
,3
]}

Bao, Ming ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Peoples R China

[2] Inner Mongolia Univ Nationalities, Coll Chem & Mat Sci, Tongliao 028000, Peoples R China

[3] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 19期

基金：

中国国家自然科学基金;

关键词：

INDOLE-2,3-DICARBOXYLIC ANHYDRIDES; BOND ACTIVATION; DIAZO-COMPOUNDS; FUNCTIONALIZATION; SYNTHONS;

D O I：

10.1021/acs.joc.0c01727

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work describes a one-step synthesis of 1H-indole-2,3-dicarboxylates through C-H activation. Rhodium-catalyzed tandem C-H activation and annulation of 2-acetyl-1-phenylhydrazines with maleates proceeded smoothly in the presence of additive NaOAc and oxidant Ag2CO3 and produced the corresponding indole derivatives, 1H-indole-2,3-dicarboxylates, in satisfactory to good yields. A variety of useful functional groups were tolerated on the benzene ring including halogen atoms (F, Cl, Br, and I) and methoxycarbonyl groups.

引用

页码：12544 / 12552

页数：9

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