Isolation and characterization of novel acetylcholinesterase inhibitors fromFicus benghalensisL. leaves

被引：22

作者：

Hassan, Heba Ali ^{[1
]}

Allam, Ahmed E. ^{[2
]}

Abu-Baih, Dalia H. ^{[3
]}

Mohamed, Mamdouh F. A. ^{[4
]}

Abdelmohsen, Usama Ramadan ^{[1
,5
]}

Shimizu, Kuniyoshi ^{[6
]}

Desoukey, Samar Y. ^{[5
]}

Hayallah, Alaa M. ^{[7
,8
]}

Elrehany, Mahmoud A. ^{[3
]}

Mohamed, Khaled M. ^{[9
]}

Kamel, Mohamed S. ^{[1
,5
]}

机构：

[1] Deraya Univ, Fac Pharm, Dept Pharmacognosy, New Minia City 61111, Egypt

[2] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Assiut 71524, Egypt

[3] Deraya Univ, Fac Pharm, Dept Biochem & Mol Biol, New Minia City 61111, Egypt

[4] Sohag Univ, Fac Pharm, Dept Pharmaceut Chem, Sohag 82524, Egypt

[5] Minia Univ, Fac Pharm, Dept Pharmacognosy, Al Minya 61519, Egypt

[6] Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Dept Agroenvironm Sci, Fukuoka 8190395, Japan

[7] Deraya Univ, Fac Pharm, Dept Pharmaceut Chem, New Minia City 61111, Egypt

[8] Assiut Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71526, Egypt

[9] Fayoum Univ, Fac Pharm, Dept Pharmacognosy, Al Fayyum 63514, Egypt

来源：

RSC ADVANCES | 2020年 / 10卷 / 60期

关键词：

ALZHEIMERS-DISEASE; ANTIOXIDANT ACTIVITY; AERIAL ROOTS; STEM BARK; CHOLINESTERASE; CEREBROSIDE; CERAMIDE; EXTRACT;

D O I：

10.1039/d0ra06565j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metabolic profiling of the crude methanolic extract ofFicus benghalensisleaves has revealed the presence of different phenolic and nitrogenous compounds including cerebrosides and tetrapyrrole pigments. A phytochemical study of the ethyl acetate fraction resulted in the identification of three known compounds, namely carpachromene (1), alpha amyrine acetate (2), and mucusoside (3) together with one new fatty acid glycoside, named 2-O-alpha-l-rhamnopyranosyl-hexacosanoate-beta-d-glucopyranosyl ester (4). The compounds were identified using 1D, 2D NMR, and HR-ESIMS techniques as well asviacomparison to other literature. Studies on the acetylcholinesterase inhibition potential and antioxidant activity were carried out on the total methanolic leaf extract, ethyl acetate fraction, and the isolated compounds. The results revealed the potent acetylcholinesterase inhibition of mucusoside alongside a new compound. Docking studies were also performed to confirm the possible interaction between the isolated compounds and acetylcholinesterase accompanying Alzheimer's disease progress.

引用

页码：36920 / 36929

页数：10

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