The Janus head of T cell aging - autoimmunity and immunodeficiency

被引：89
作者：
Goronzy, Joerg J. [1 ,2 ]
Li, Guangjin [1 ,2 ]
Yang, Zhen [1 ]
Weyand, Cornelia M. [1 ,2 ]
机构：
[1] Stanford Univ, Div Rheumatol & Immunol, Dept Med, Sch Med, Stanford, CA 94305 USA
[2] Palo Alto Vet Adm Hlth Care Syst, Dept Med, Palo Alto, CA USA
来源：
FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷
基金：
美国国家卫生研究院;
关键词：
immunosenescence; autoimmunity; inflammation; pathogenesis; DNA damage response; T cell receptor signaling; rheumatoid arthritis; giant cell arteritis;
D O I：
10.3389/fimmu.2013.00131
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune aging is best known for its immune defects that increase susceptibility to infections and reduce adaptive immune responses to vaccination. In parallel, the aged immune system is prone to autoimmune responses and many autoimmune diseases increase in incidence with age or are even preferentially encountered in the elderly. Why an immune system that suboptimally responds to exogenous antigen fails to maintain tolerance to self-antigens appears to be perplexing. In this review, we will discuss age-associated deviations in the immune repertoire and the regulation of signaling pathways that may shed light on this conundrum.
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页数：10
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