A new development in DNA repair modulation Discovery of a BLM helicase inhibitor

被引：8

作者：

Banerjee, Taraswi ^{[1
]}

Aggarwal, Monika ^{[2
]}

Brosh, Robert M., Jr. ^{[1
]}

机构：

[1] NIA, Lab Mol Gerontol, NIH, Biomed Res Ctr, Baltimore, MD 21224 USA

[2] Georgetown Univ, Med Ctr, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA

来源：

CELL CYCLE | 2013年 / 12卷 / 05期

关键词：

GENE;

D O I：

10.4161/cc.23953

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：713 / 714

页数：2

共 8 条

[1] Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress [J].

Aggarwal, Monika ;

Sommers, Joshua A. ;

Shoemaker, Robert H. ;

Brosh, Robert M., Jr. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (04) :1525-1530

[2] RecQ helicases: multifunctional genome caretakers [J].

Chu, Wai Kit ;

Hickson, Ian D. .

NATURE REVIEWS CANCER, 2009, 9 (09) :644-654

[3] THE BLOOMS-SYNDROME GENE-PRODUCT IS HOMOLOGOUS TO RECQ HELICASES [J].

ELLIS, NA ;

GRODEN, J ;

YE, TZ ;

STRAUGHEN, J ;

LENNON, DJ ;

CIOCCI, S ;

PROYTCHEVA, M ;

GERMAN, J .

CELL, 1995, 83 (04) :655-666

[4] Syndrome-causling mutations of the BLM gene in persons in the Bloom's syndrome registry [J].

German, James ;

Sanz, Maureen A. ;

Ciocci, Susan ;

Ye, Tian Z. ;

Ellis, Nathan A. .

HUMAN MUTATION, 2007, 28 (08) :743-753

[5] A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells [J].

Giang Huong Nguyen ;

Dexheimer, Thomas S. ;

Rosenthal, Andrew S. ;

Chu, Wai Kit ;

Singh, Dharmendra Kumar ;

Mosedale, Georgina ;

Bachrati, Csanad Z. ;

Schultz, Lena ;

Sakurai, Masaaki ;

Savitsky, Pavel ;

Abu, Mika ;

McHugh, Peter J. ;

Bohr, Vilhelm A. ;

Harris, Curtis C. ;

Jadhav, Ajit ;

Gileadi, Opher ;

Maloney, David J. ;

Simeonov, Anton ;

Hickson, Ian D. .

CHEMISTRY & BIOLOGY, 2013, 20 (01) :55-62

[6] Homologous recombination in cancer development, treatment and development of drug resistance [J].

Helleday, Thomas .

CARCINOGENESIS, 2010, 31 (06) :955-960

[7] Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors [J].

Murai, Junko ;

Huang, Shar-yin N. ;

Das, Benu Brata ;

Renaud, Amelie ;

Zhang, Yiping ;

Doroshow, James H. ;

Ji, Jiuping ;

Takeda, Shunichi ;

Pommier, Yves .

CANCER RESEARCH, 2012, 72 (21) :5588-5599

[8] An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression [J].

Srivastava, Mrinal ;

Nambiar, Mridula ;

Sharma, Sheetal ;

Karki, Subhas S. ;

Goldsmith, G. ;

Hegde, Mahesh ;

Kumar, Sujeet ;

Pandey, Monica ;

Singh, Ram K. ;

Ray, Pritha ;

Natarajan, Renuka ;

Kelkar, Madhura ;

De, Abhijit ;

Choudhary, Bibha ;

Raghavan, Sathees C. .

CELL, 2012, 151 (07) :1474-1487

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