Desferrioxamine-cadmium as a 'Trojan horse' for the delivery of Cd to bacteria and fungi

被引：11

作者：

Costa Mattos, Ana Luiza ^{[1
]}

Leopoldo Constantino, Vera Regina ^{[1
]}

Alves de Couto, Ricardo Alexandre ^{[1
]}

Luna Pinto, Delia Manuela ^{[2
]}

Kaneko, Telma Mary ^{[2
]}

Esposito, Breno Pannia ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim, Lab Quim Bioinorgan Ambiental & Metalofarmacos, BR-05508000 Sao Paulo, Brazil

[2] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-05508000 Sao Paulo, Brazil

来源：

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2013年 / 27卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Cadmium; Desferrioxamine; Escherichia coli; Pseudomonas aeruginosa; Candida albicans; RARE-EARTH-ELEMENTS; IRON ACQUISITION; PSEUDOMONAS-AERUGINOSA; SIDEROPHORES; ACID; FERRIOXAMINE; CHEMISTRY; TRANSPORT; GROWTH;

D O I：

10.1016/j.jtemb.2012.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecules naturally designed for the acquisition of essential metals can be used as a shuttle to deliver toxic metal ions to target organisms. In this study, we describe for the first time the synthesis of a derivative of cadmium and desferrioxamine B, a bacterial siderophore. The new compound was characterized by elemental analysis, vibrational (infrared and Raman) spectroscopy, mass coupled thermal analyses and X-ray diffraction methods. Studies on the in vitro toxicity toward a fungus and two bacterial strains indicated that the coordination compound is more active against microrganisms than cadmium chloride on a Cd-concentration basis, indicating that desferrioxamine can work as a "Trojan horse" in the delivery of a toxic metal. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：103 / 108

页数：6

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